Uv-induced Dna Damage And Repair A Review Pdf Readers
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Chromatin is organized into higher-order structures that form subcompartments in interphase nuclei. Different categories of specialized enzymes act on chromatin and regulate its compaction and biophysical characteristics in response to physiological conditions. We present an overview of the function of chromatin structure and its dynamic changes in response to genotoxic stress, focusing on both subnuclear organization and the physical mobility of DNA.
- DNA Damage & Repair: Mechanisms for Maintaining DNA Integrity
- Chromatin and nucleosome dynamics in DNA damage and repair
- Impact of the Circadian Clock on UV-Induced DNA Damage Response and Photocarcinogenesis.
DNA Damage & Repair: Mechanisms for Maintaining DNA Integrity
Chromatin and nucleosome dynamics in DNA damage and repair
Purpose : The purpose of this study was to investigate the mechanisms by which miR may contribute to the phenotypic alterations associated with stress-induced senescence of human trabecular meshwork HTM cells. Conclusions : Our results suggest that the observed up-regulation of miR after stress-induced senescence in HTM cells may contribute to reinforce cellular senescence by inhibiting cell cycle progression through multiple gene targets and limiting the DNA repair mechanisms through inhibition of KIAA Purchase this article with an account. Jump To Open Access. Alerts User Alerts. You will receive an email whenever this article is corrected, updated, or cited in the literature.
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Sinha and D. Sinha , D. Increases in ultraviolet radiation at the Earth's surface due to the depletion of the stratospheric ozone layer have recently fuelled interest in the mechanisms of various effects it might have on organisms. DNA is certainly one of the key targets for UV-induced damage in a variety of organisms ranging from bacteria to humans.
Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. The contributions of these processes to the somatic mutation load in the skin of healthy humans has so far not been accurately assessed because the low numbers of mutations from current sequencing methodologies preclude the distinction between sequencing errors and true somatic genome changes. In this work, we sequenced genomes of single cell-derived clonal lineages obtained from primary skin cells of a large cohort of healthy individuals across a wide range of ages. We report here the range of mutation load and a comprehensive view of the various somatic genome changes that accumulate in skin cells. We demonstrate that UV-induced base substitutions, insertions and deletions are prominent even in sun-shielded skin. In addition, we detect accumulation of mutations due to spontaneous deamination of methylated cytosines as well as insertions and deletions characteristic of DNA replication errors in these cells.
Impact of the Circadian Clock on UV-Induced DNA Damage Response and Photocarcinogenesis.
Global genome nucleotide excision repair removes DNA damage from transcriptionally silent regions of the genome. Relatively little is known about the molecular events that initiate and regulate this process in the context of chromatin. We've shown that, in response to UV radiation—induced DNA damage, increased histone H3 acetylation at lysine 9 and 14 correlates with changes in chromatin structure, and these alterations are associated with efficient global genome nucleotide excision repair in yeast.
Being sessile, plants are continuously exposed to DNA-damaging agents present in the environment such as ultraviolet UV and ionizing radiations IR. The outcome of the discussion may be helpful in devising future research in the current context. Having sessile nature, plants have to cope with constant exposure of environmental stressors which includes UV-B, ozone, desiccation, rehydration, salinity, low and high temperature, and air and soil pollutants including metals-metalloids.
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