Ophthalmic Preparations Formulation And Evaluation Pdf

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ophthalmic preparations formulation and evaluation pdf

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Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology.

Review on Basic Concept for Ophthalmic Preparations

The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, ciprofloxacin, which is used in the treatment of eye infection such as dacrocystitis, bacterial conjunctivitis, corneal ulceration and blepharitis, based on the concepts of ph-triggered in-situ gelation, thermo reversible gelation and Ion activated system. Poly acrylic acid Carbopol was used as the gelling agent in combination of hydroxy propyl methylcellulose, which acted as a viscosity-enhancing agent. Gellan gum Gelrite is an anionic exocellular polysaccharide by the bacterium pseudo Monas elodea, having the characteristic property cation-induced gelation 0. The developed system is thus a viable alternative to conventional eye drops. A high frequency of eye drop instillation is associated with patient non-compliance. Inclusion of excess drug in the formulation in an attempt to overcome bioavailability problem is potentially dangerous if the drug solution drained from the eye is systemically absorbed from the nasolacrimal duct 9,

FORMULATION AND EVALUATION OF SOME SELECTED TIMOLOL MALEATE OPHTHALMIC PREPARATIONS

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Background and objective: Ocular drug delivery research is challenging due to the presence of anatomical and physiological barriers. The ophthalmic preparation of diclofenac sodium DC for relieving ocular inflammation is presently available in the market only as an eye drop solution with low ocular bioavailability. Methods : Formulation was developed and optimized for three different variables chondroitin sulfate, chitosan, and initial drug concentration. The developed formula was evaluated by various in-vitro parameters such as particles' size, entrapment efficacy, zeta potential, and in vitro release profile. Results : The particles' size, entrapment efficacy, and zeta potential of the best formulation were found to be Furthermore, the best formulation showed a biphasic release profile, initial burst release in the first hour, followed by sustained release within 24hours. Conclusion : Promising results of in-vitro studies indicated that CS-CH-NPs could be a potential substitute for improved ocular delivery of diclofenac sodium.

Objective: This work aims to formulate and evaluate an ophthalmic in-situ gel of ciprofloxacin hydrochloride HCl using poloxamer P as a gelling agent and hydroxypropyl methylcellulose HPMC as a viscosity modifier. The objective of this work was to prolong the contact time as the in-situ gel will be converted into a gel upon contact with the cul-de-sac. Methods: Ciprofloxacin HCl ophthalmic in-situ gel was prepared by utilizing P as a temperature-dependent polymer while hydroxypropyl methylcellulose was used as a viscosity modifier. The system was evaluated for physical appearance, pH, drug content, sterility, irritancy and stability. In addition, gelation temperature and a viscosity at different shear rates and different temperatures were studied.


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Extemporaneous Ophthalmic Preparations

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Preparation and Evaluation of In-Situ-Gels for Ocular Drug Delivery

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4 Comments

  1. Barbie P. 16.05.2021 at 13:49

    This book provides a list of concise extemporaneous ophthalmic preparations, and standardizes the formulation of the products by suggesting specific strength, route of administration, appropriate vehicle, and method of preparation.

  2. Artus L. 23.05.2021 at 11:42

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