Vascular And Neurogenic Rejuvenation In Aging Mice By Modulation Of Asm Pdf

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vascular and neurogenic rejuvenation in aging mice by modulation of asm pdf

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Although many studies have reported that the breakdown of the blood-brain barrier BBB represents one of the major pathological changes in aging, the mechanism underlying this process remains relatively unexplored. In this study, we described that acid sphingomyelinase ASM derived from endothelial cells plays a critical role in BBB disruption in aging.

Electronic address:. Toggle navigation. Login Categories Journals. Publications by authors named "Minseok Kang".

Publications by authors named "Minseok Kang"

By cleaving sphingomyelin into ceramide, which is an essential component of plasma membrane microdomains, acid sphingomyelinase Asm pivotally controls cell signaling. Acid sphingomyelinase Asm , which catalyzes the hydrolysis of sphingomyelin to ceramide, is a key enzyme in sphingolipid metabolism. Localized in lysosomes, Asm is translocated to the plasma membrane within a few seconds to minutes upon stress stimuli [ 1 , 2 , 3 ]. In plasma membranes, ceramide clusters into membrane platforms that critically control the activity of signal pathways modifying cell survival and death [ 1 , 2 , 4 , 5 ]. Importantly, the pharmacological inhibition or genetic depletion of Asm in mice conferred protection against cystic fibrosis, lung infection and sepsis [ 15 , 16 ], whereas Asm-dependent and -independent ceramide formation was found to be required for radiation-induced tumor apoptosis [ 10 , 17 ]. Hence, the deactivation of Asm represents a potent strategy for the prevention of cell injury in a wide range of pathologies.

Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying the transition from a young-and-healthy to aged-and-dysfunctional brain are not well understood. Here, we report breakdown of the vascular blood-brain barrier BBB in aging humans and rodents, which begins as early as middle age and progresses to the end of the life span. Last, we found that this same signaling pathway is activated in aging human subjects with BBB dysfunction. Our study identifie Continue Reading.

Acid sphingomyelinase-mediated blood-brain barrier disruption in aging

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Neuron , 27 Sep , 1 : Read article at publisher's site DOI : Biomolecules , 10 10 , 23 Sep Nat Commun , 11 1 , 23 Jun

The impact of endothelial cell death in the brain and its role after stroke: A systematic review

Sundaram SM, Schwaninger M. Trends Endocrinol Metab. Epub ahead of print. A combined epidemiological-experimental approach. Br J Clin Pharmacol.

Age is associated with altered immune functions that may affect the brain. In this review, we explore novel mechanisms by which the aging immune system alters central nervous system functions and neuroimmune responses, with a focus on brain barriers. Understanding how age alters BBB functions and responses to pathological insults could provide important insight on the role of the BBB in the progression of cognitive decline and neurodegenerative disease. Advances in modern medicine, nutrition, hygiene, and safety standards have doubled the life expectancy of humans worldwide over the last century and a half [ 1 ]. Therefore, it is imperative that the scientific and medical communities investigate approaches that will minimize age-associated disease and maximize quality of life.

Он потянул сильнее. Труп сдвинулся еще чуть-чуть. Тогда Стратмор напрягся и рванул тело изо всех сил. Внезапно его швырнуло назад, и он больно ударился спиной о кожух генератора.

Сьюзан отгородилась от царившего вокруг хаоса, снова и снова перечитывая послание Танкадо. PRIME DIFFERENCE BETWEEN ELEMENTS RESPONSIBLE FOR HIROSHIMA AND NAGASAKI ГЛАВНАЯ РАЗНИЦА МЕЖДУ ЭЛЕМЕНТАМИ, ОТВЕТСТВЕННЫМИ ЗА ХИРОСИМУ И НАГАСАКИ - Это даже не вопрос! - крикнул Бринкерхофф.

Беккер задумался: Я бы хотел, чтобы ты как следует вымыл голову, научился говорить по-человечески и нашел себе работу. Но решил, что хочет от этого парня слишком многого. - Мне нужна кое-какая информация, - сказал .

Но он не был готов к тому, что произошло в следующее мгновение. Сохраняя ледяное спокойствие, Сьюзан ткнула указательным пальцем в твердокаменную грудь Хейла и заставила его остановиться. Хейл в шоке отпрянул, поняв, что она не шутит: Сьюзан Флетчер никогда еще до него не дотрагивалась, даже руки не коснулась. Правда, это было не то прикосновение, какое он рисовал в воображении, представляя себе их первый физический контакт, но все же… Хейл долго с изумлением смотрел на нее, затем медленно повернулся и направился к своему терминалу. Одно ему было абсолютно ясно: распрекрасная Сьюзан Флетчер бьется над чем-то очень важным, и можно поклясться, что это никакая не диагностика.

Может, ему просто показалось. Какая разница, Стратмор никогда не решится выстрелить, пока он прикрыт Сьюзан. Но когда он начал подниматься на следующую ступеньку, не выпуская Сьюзан из рук, произошло нечто неожиданное. За спиной у него послышался какой-то звук.

Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions


  1. Rhys F. 26.05.2021 at 16:12

    Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM. Author links Brain endothelial cell is a main contributor of increased ASM in aging. •. Increased Download: Download Acrobat PDF file (12MB).

  2. Dallas H. 30.05.2021 at 12:28

    Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM Increased ASM in aging causes BBB impairment and neuronal.

  3. Nuriya O. 31.05.2021 at 14:22

    Cell Stress, Vol.

  4. Dexter d. L. 02.06.2021 at 02:20

    Eur J Endocrinol.